A bus crashed on the A165 at Ganstead.
The double-decker Stagecoach bus left the road and came to a halt in the garden of a house.
The bus was in collision with a car. The car then spun into a Land Rover.
However, there were no serious injuries.
Four ambulances, three fire engines and police attended the accident, north of Bilton.
An eyewitness said: "It is chaos. Police are everywhere."
The road was closed in both directions until around 5.30pm.
Police said the accident happened shortly before 2pm.
A silver Astra and a blue Land Rover were involved.
Three people who were on the bus are being treated for what are believed to be non life-threatening injuries.
Two people, who are thought to have been travelling in the Astra, are also receiving treatment for minor injuries.
Longdales Lane was also closed.Updated 6pm.
