The incident happened on Tuesday, September 16.
It is believed four men took the caravan, worth about £2,000, from the owner's driveway in Hessle High Road before attaching it to a large, black vehicle and driving off.
The caravan is a green Abi Award Tristar. It had a number of belongings inside including new shoes, DVDs and CDs.
Owner Tina Dalee said: "We couldn't believe it when we realised our caravan had been taken from our driveway.
"What is the world coming to when that happens?
"It was then spotted by people being driven over the flyover in west Hull.
"We hadn't used the caravan yet, but we were really looking forward to it. It is just a massive shame and we are really angry that anyone would target us."
It is estimated the belongings inside the caravan are worth several hundred pounds.
Husband Nigel Dalee said: "We want our caravan back as soon as possible and hopefully someone out there knows where it is.
"I called the police minutes after it happened, but I had to wait an age for someone to come out to me."
Anyone with information should call Humberside Police on 101.
