Humberside Airport is offering flights to Switzerland for the first time.
They will provide a transport link with Berne for six weeks in winter.
The services are aimed at skiers, with the destination about an hour from the Grindelwald and Interlaken resorts in the mountainous Jungfrau region.
Commercial director Paul Litten expects demand to be very strong.
He said: "We have been working with Oska Travel, who recently announced November and April flights direct to Antalya in Turkey, to develop a programme of direct flights to Switzerland.
"The team have been working hard to provide services that our customers want.
"With the return of Thomson airways next year for a 26 week period, additional services to Malaga, Alicante, Palma, Bulgaria, Jersey, Turkey, Italy and fly cruises from Barcelona and Venice, we believe the airport is turning the corner of developing more routes to winter and summer destinations."
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