An ambulance is on the scene after a van and car crashed on Great Union Street.
Paramedics are treating casualties for minor injuries although the road is closed both ways between St Peter Street and the A63 Garrison Road.
The crash happened shortly before 3pm between a white Ford Transit and a silver Mondeo.
The road is closed from the Myton Bridge roundabout and drivers are also being warned of hazardous driving conditions because of snow on the A166 between the A614 junction in Driffield and the Beacon Road junction in Garrowby Hill.
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